Biophysics of the Cytoskeleton


Awarded the Innovator Inquiry Award and Provost Research Grant

I have been awarded an independent research grant to study how living organisms control their shape and size. As part of this, we will be developing a giant single-celled ciliate as a model organism for studying onrganismal size-control. This work will be carried out in collaboration with Profs Jack Costello (MBL), Wallace Marshall (UCSF) and Eva Kanso (USC). More on this coming soon!

May 2018

Speaking at the New England Society for Microscopy (NESM)

Honoured to have been invited to speak about our work on molecular mechanisms regulating size-scaling in living organisms at the spring meeting of the New England Society for Microscopy. Thanks a lot to NESM President Mikael Garabedian for inviting and hosting me at NESM.

March 8th, 2018

Publication in Current Protocols in Cell Biology

My detailed protocol on using microfluidics for studying dynamics of single actin filaments has just been published. Thanks a lot to Jennifer Lippincott-Schwartz for inviting me to do this.

December 18th, 2017

Awarded the HHMI Interfaces Scholar Award

As part of the award, I will be giving a lecture titled "Quantitative Biology of Cell Migration". Come listen to me talk at the Annual Quantitative Biology Bootcamp on January 9th.

December 8th, 2017

Paper published Current Biology

Our paper showing the first direct visual evidence of the dual effects of depolymerizing as well as severing effect of Actin Depolymerizing Effect (ADF) on actin filaments has been published in Current Biology. Using a novel microfluidics-inspired approach, we also provide the first direct evidence for Capping Protein's monomer funneling behaviour, and how CP collaborates with ADF to enhance motility.

June 15th, 2017

Manuscript accepted in Current Biology

Our manuscript showing first direct visual evidence of the depolymerizing effect of ADF on actin filaments has just been accepted for publication at Current Biology. Our work brings resolution to the age-old debate on ADF function - does it fragment or cause rapid depolymerization of actin filaments? We show that it does both! Using a novel microfluidics-inspired approach, we also provide the first direct evidence for Capping Protein's monomer funneling behaviour, and how CP collaborates with ADF to enhance motility.

An earlier version of the manuscript is available on bioRxiv .

April 27th, 2017

Review published in Nature Reviews Molecular Cell Biology

Our Review on the regulation of size of intracellular actin monomer pool and how this pool enhances the rate of actin-based motility has just been published. Actin turnover plays a central role in a number of intracellular processes like cell migration, wound healing and cell division.

March 7th, 2017

Whitman early career fellowship

Awarded the Whitman early career award for 2017. The fellowship enables scientists in the early stages of their scientific careers to conduct independent summer research at the Marine Biology Laboratory in Woods Hole. The overarching goal of my proposed research is to study how size-control occurs in biological systems, both at the level of single cells as well as the molecular cytoskeletal elements. We will use a giant single-celled protist as a model system for this study.

January 20th, 2017

Moving to Boston

Just moved to Brandeis University, where I will be working jointly between the labs of Jeff Gelles and Bruce Goode. We will combine single-filament imaging with single-molecule imaging to study how different cytoskeletal elements cross-regulate each other. I am also looking forward working with Jané Kondev on the theoretical aspects of filament length control.

January 1st, 2017

Summer Research at Marine Biology Laboratory, Woods Hole (USA)

I will be spending the summer working as a visiting researcher at the Marine Biology Laboratory. Together with Wallace Marshall (UCSF) and Jack Costello (Providence College), we will be studying biological fluid-flows generated by ciliates. A huge thanks to Wallace for helping make this happen! A big thanks also to the physiology course and the course co-directors Jennifer Lippincott-Schwartz and Rob Phillips for their support.

July 1st, 2016

"Grand Advances in Biology" Prize by the French Academy of Science

Awarded "Les grandes avancées françaises en biologie" prize by the French Academy of Science for the year 2016. As part of the prize, Marie-France and I will present our recent work to the academy on June 21st, 2016. The prize recognizes our recent studies on size-control of actin filaments as well as that of higher-order actin structures. These studies have recently been published in Nature Communications (2015) and Developmental Cell (2016).
CNRS News Release

June 14th, 2016